物流网络快速应对疫情的策略与体系设计

物流业既是抗击新冠肺炎疫情的主力军,也是受疫情冲击最严重的行业之一.在讨论疫情中不同地区物资需求类型和特性、运输方式和瓶颈因素的基础上,总结物流业在重点地区物资保障、国内城市配送与快递服务,以及国际供应链与产业链协同中的重要作用.从高效组网、智能化两方面揭示政策和技术支撑下的物流网络快速响应策略.从物流业全面复工复产视角,解析以重点区域、重要节点和重点企业为核心的分阶段快速恢复策略.最后,构建以参与主体、组织主体、运行载体和信息保障等为核心的应急物流网络体系设计框架,并提出具体实施建议.     

船用EH36高强钢无缝药芯焊丝焊接接头组织和冲击韧性研究

本文以SRSF501无缝药芯焊丝在船用EH36高强钢中的焊接应用为目的,研究了国产无缝药芯焊丝SRSF501在船用EH36高强钢焊接中的组织和冲击韧性。通过试验表明：SRSF501焊接EH36钢接头各区域的冲击性能均满足船级社要求；多层多道焊时,焊缝组织由粗大的柱状组织和细小的等轴晶组织组成,底层焊缝和末道焊缝柱状晶区域较大；盖面层两侧接头热影响区存在粗晶区,其它位置接头的热影响区不存在粗晶区；焊接接头中熔合线外2mm处,晶粒最细,冲击韧性最好。     

开县平桥片区切坡治理地质环境评价分析

通过对场地工程地质条件及水文地质条件,以及切坡的稳定性和地基进行相关评价,为切坡的合理处治提供科学依据。     

移动闭塞系统区间通过能力分析及参数计算

移动闭塞条件下“闭塞分区”呈现出“移动”和“长度变化”的特征,其区间通过能力的计算较固定闭塞系统更加复杂。本文建立了移动闭塞系统区间通过能力的数学模型,对区间通过能力与列车追踪运行速度、跟驰车距和列车性能等参数之间的相互关系进行了定性、定量分析,并就关鍵参数的计算方法进行了深入的讨论,对移动闭塞条件下的列车运行控制与行车组织有一定的参考价值。     

双层开孔斜挡板透空式防波堤消浪性能研究

针对一种新型双层开孔斜挡板透空式防波堤消浪性能问题,研究挡板开孔率和挡板倾斜角度对防波堤消浪性能的影响。采用物理模型试验方法,得出其反射和透射系数、波能分布和堤后波幅频谱特征结果。结果表明,斜挡板开孔率越大,防波堤透射系数也越大,但在试验范围内,透射系数均小于0. 5;该类型防波堤对波浪有较好的消能性,对较长周期波以反射为主,较短周期波以消浪室消能为主,整体透射系数较短周期波略大;防波堤设计斜挡板比平挡板透射系数小,具有更好的消浪性能,最小透浪仅为后者的39%。     

Numerical Simulation of Float-Over Installation for Offshore Platform

In this paper, a numerical investigation of a float-over installation for an offshore platform is presented to verify the feasibility of the actual installation. The hydrodynamic performance of a T-barge is investigated in the frequency domain, and the coupled motions are analyzed in the time domain. We then compare with those of the model test and determine that the response amplitude operator and the time series agree quite well. The barge exhibits favorable hydrodynamic behavior in the considered sea state, and the equipment loads are allowable. The mooring system and sway fender forces are within the permissible range. Based on these results, we can verify that the actual installation of the offshore platform is feasible. We accurately simulated many important factors and effectively reduced the risk associated with the offshore installation, which is of great importance. As such, we demonstrate that the numerical simulation of the float-over installation for offshore platforms has practical engineering significance.     

螺柱焊在船舶焊接卡马中的应用

本文介绍了螺柱焊焊接工艺及其在船舶焊接卡马中的应用,并结合实船使用情况,对螺柱式焊接卡马和普通焊接卡马在工效和成本方面进行了对比分析。     

Novel experimental strategy for high resolution AFM imaging of membrane-associated bacterial toxins

Bacterial pore-forming toxins （PFTs） are essential virulence factors of many human pathogens. Knowl- edge of their structure within the membrane is critical for an understanding of their function in pathogenesis and for the development of useful therapy. Atomic force microscopy （AFM） has often been employed to structurally interrogate many membrane proteins, including PFTs, owing to its ability to produce sub-nanometer resolution images of samples under aqueous solution. However, an absolute prerequisite for AFM studies is that the samples are single-layered and closely-packed, which is frequently challenging with PFTs. Here, using the prototypical member of the cholesterol-dependent cytolysin family of PFTs, perfringolysin O （PFO）, as a test sample, we have developed a simple, highly robust method that routinely produces clean, closely-packed samples across the entire specimen surface. In this approach, we first use a small Teflon well to prepare the supported lipid bilayer, remove the sample from the well, and then directly apply the proteins to the bilayer. For reasons that are not clear, bilayer preparation in the Teflon well is essential. We anticipate that this simple method will prove widely useful for the preparation of similar samples, and thereby enable AFM imaging of the greatest range of bacterial PFTs to the highest possible resolution.     

主动铰接盾构在连续小半径曲线中风化泥岩的掘进控制技术

武汉市轨道交通11号线东段工程光谷四路站—光谷五路站区间为"S"型连续曲线,最小平曲线半径为350 m,采用盾构法施工。通过对主动铰接盾构机掘进控制的难点分析,从土压力、千斤顶推力、千斤顶行程差、水平铰接角度和前盾水平趋向等方面采取有针对性的技术控制措施,使成型隧道轴线、管片错台控制在规范允许范围之内,成功解决了连续小半径曲线隧道盾构施工轴线难以控制、管片容易错台等大问题。     

氧化苦参碱对慢性肾脏病患者血清TGF-β1和Col Ⅲ的影响

目的观察氧化苦参碱对慢性肾脏病(CKD)患者血清转化生长因子-β1(TGF-β1)、Ⅲ型胶原(ColⅢ)的影响,探讨其在肾间质纤维化发生发展过程中的作用和治疗价值。方法选取健康对照者10例、慢性肾脏病患者40例,根据肾小球滤过率(GFR)分为轻度肾损害组(GFR<90 mL/min.1.73 m2,CKDⅠ)、中重度肾损害组(GFR<60 mL/min.1.73 m2,CKDⅡ),再分层随机抽样,分为常规治疗组和氧化苦参碱组。利用双抗体夹心酶联免疫吸附法分别检测各研究对象治疗前、后血清TGF-β1、ColⅢ含量,采用t检验比较两组TGF-β1、ColⅢ水平的差异。结果氧化苦参碱组TGF-β1、ColⅢ含量显著低于常规治疗组(P<0.05)。结论氧化苦参碱可能通过下调TGF-β1、ColⅢ水平,减少ECM沉积,从而达到防止肾间质纤维化的作用。